Article

CRISPR/Cas9-mediated deletion of Shp1 and Shp2 reveals distinct roles in human megakaryopoiesis and proplatelet formation

2026-07-24

Abstract excerpt

The non-receptor protein-tyrosine phosphatases Shp1 ( PTPN6 ) and Shp2 ( PTPN11 ) play critical roles in hematopoietic signaling networks, yet their specific functions in human megakaryopoiesis and thrombopoiesis remain incompletely understood. While Shp2 is recognized in murine models as a positive regulator of thrombopoietin (Tpo)-mediated signaling through the Ras/MAPK and PI3K/AKT pathways, Shp1 has been imp...

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Literature Corpus work: 2a0b4f2e-134e-54de-ad12-1351d5bf1ede
DOI: 10.64898/2026.07.23.735226

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CRISPR/Cas9-mediated deletion of Shp1 and Shp2 reveals distinct roles in human megakaryopoiesis and proplatelet formationDOI 10.64898/2026.07.23.735226Read

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