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Article

Impact of the serum- and glucocorticoid-inducible kinase 1 on platelet dense granule biogenesis and secretion.

Journal of thrombosis and haemostasis : JTH - 1 Jul 2015

Walker B, Schmid E, Russo A, Schmidt E-M, Burk O, Münzer P, Velic A, Macek B, Schaller M, Schwab M, Seabra M C, Gawaz M, Lang F, Borst O

Abstract excerpt

BACKGROUND: Platelet secretion is critical to development of acute thrombotic occlusion. Platelet dense granules contain a variety of important hemostatically active substances. Nevertheless, biogenesis of platelet granules is poorly understood. OBJECTIVES: Serum- and glucocorticoid-inducible kinase 1 (SGK1) has been shown to be highly expressed in platelets and megakaryocytes, but its role in the regulation of...

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Identifiers

PMID: 25944668
DOI: 10.1111/jth.12998

Genes

SGK1

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