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Article

A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis

12 Nov 2012

Abstract excerpt

Millions of platelets are produced each hour by bone marrow (BM) megakaryocytes (MKs). MKs extend transendothelial proplatelet (PP) extensions into BM sinusoids and shed new platelets into the blood. The mechanisms that control platelet generation remain incompletely understood. Using conditional mutants and intravital multiphoton microscopy, we show here that the lipid mediator sphingosine 1-phosphate (S1P)...

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Share to Lipid Membrane Structure and Behavior
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PMID: 23148237
DOI: 10.1084/jem.20121090

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