Article
Expression and function of mutant Ia antigen in transgenic mice.
Transplantation - 1 Oct 1990
Wei B Y, Martin J, Little R, Anderson G, Savarirayan S, Buerstedde J M, McKean D, David C
Abstract excerpt
Cell surface expression of Ia antigens requires the assembly of alpha and beta heterodimers. We have produced a double transgenic mouse with a wild form Ak alpha gene and a mutant Ak beta (Ak beta MB) gene with d-allele substitution at positions 63 and 65-67. Initial studies indicated that the Ak alpha and Ak beta MB transgenes are not expressed on the surface of lymphoid cells of the transgenic mice. However,...
Topics
- Animals
- Gene Expression
- Histocompatibility Antigens Class II
- Isoantigens
- Lipopolysaccharides
- Mice
- Mice, Transgenic
- Mutation
- Skin Transplantation