Article
Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.
The Journal of experimental medicine - 1 Jun 1993
Bikoff E K, Huang L Y, Episkopou V, van Meerwijk J, Germain R N, Robertson E J
Abstract excerpt
We used gene targeting techniques to produce mice lacking the invariant chain associated with major histocompatibility complex (MHC) class II molecules. Cells from these mice show a dramatic reduction in surface class II, resulting from both defective association of class II alpha and beta chains...
Topics
- Animals
- Antigens, Differentiation, B-Lymphocyte
- Antigens, Surface
- Biological Transport
- CD4-Positive T-Lymphocytes
- Cells, Cultured
- Hematopoietic Stem Cells
- Histocompatibility Antigens Class II
- Mice
- Mice, Inbred C57BL
- Mutation
- Peptide Fragments