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Article

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

The Journal of experimental medicine - 1 Jun 1993

Bikoff E K, Huang L Y, Episkopou V, van Meerwijk J, Germain R N, Robertson E J

Abstract excerpt

We used gene targeting techniques to produce mice lacking the invariant chain associated with major histocompatibility complex (MHC) class II molecules. Cells from these mice show a dramatic reduction in surface class II, resulting from both defective association of class II alpha and beta chains and markedly decreased post-Golgi transport. The few class II alpha/beta heterodimers reaching the cell surface behave...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 8098731
DOI: 10.1084/jem.177.6.1699
PMCID: PMC2191043

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Source receipt: pubmed, retrieved 7 Sept 2026.

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