Article
The effect of excess beta-chain synthesis on cell-surface expression of allele-mismatched class II heterodimers in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1990
Gilfillan S, Aiso S, Michie S A, McDevitt H O
Abstract excerpt
We have recently described 12 lines of H-2s/s mice carrying from 1 to 65 copies of an A beta k transgene. The transgene was coexpressed with the endogenous allele, and A beta K mRNA expression correlated well with transgene copy number. Overexpression of the transgene was associated with a variet...
Topics
- Alleles
- Animals
- Antibodies, Monoclonal
- B-Lymphocytes
- Blotting, Northern
- Blotting, Southern
- Cell Membrane
- Crosses, Genetic
- DNA
- Female
- Gene Expression
- Genes, MHC Class II
- Histocompatibility Antigens Class II
- Humans
- Macromolecular Substances
- Male
- Mice
- Mice, Transgenic