Article
The effect of excess beta-chain synthesis on cell-surface expression of allele-mismatched class II heterodimers in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1990
Gilfillan S, Aiso S, Michie S A, McDevitt H O
Abstract excerpt
We have recently described 12 lines of H-2s/s mice carrying from 1 to 65 copies of an A beta k transgene. The transgene was coexpressed with the endogenous allele, and A beta K mRNA expression correlated well with transgene copy number. Overexpression of the transgene was associated with a variety of defects, including a significant reduction in I-A cell-surface expression. In this paper, we assess the effect of...
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