Article
Expression of I-A alpha k and allelic restriction on A alpha/A beta pairing in transgenic mice.
Journal of immunogenetics - 1 Jan 2000
Martin J, Wei B Y, Savarirayan S, David C S
Abstract excerpt
Cell surface expression of class 11 major histocompatibility complex encoded (1a) molecules depends on association of the component alpha and beta chain into a stable heterodimer. Studies on cell lines transfected with MHC class II genes have revealed important limitations on the assembly of haplotype-mismatched A alpha:A beta complex. In order to study alpha:beta chain pairing restrictions in vivo a number of...
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