A conservative mutation in a class I MHC molecule outside the peptide binding groove stimulates responses to self peptides.

Article

A conservative mutation in a class I MHC molecule outside the peptide binding groove stimulates responses to self peptides.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1993

Grandea A G, Bevan M J

Abstract excerpt

A transgenic mouse has been made that expresses a mutant MHC class I H-2Kb molecule with glutamic acid at position 65 (E65) in place of glutamine. The side chain at position 65, on the outward face of the alpha-helix of the alpha 1 domain of the class I molecule, interacts with the TCR, and not w...

Topics

Animals
Cell Line
Cross Reactions
H-2 Antigens
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Mice, Transgenic
Mutation
Peptide Fragments
Structure-Activity Relationship
T-Lymphocytes, Cytotoxic

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