Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A conservative mutation in a class I MHC molecule outside the peptide binding groove stimulates responses to self peptides.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1993

Grandea A G, Bevan M J

Abstract excerpt

A transgenic mouse has been made that expresses a mutant MHC class I H-2Kb molecule with glutamic acid at position 65 (E65) in place of glutamine. The side chain at position 65, on the outward face of the alpha-helix of the alpha 1 domain of the class I molecule, interacts with the TCR, and not with the peptide binding groove. The transgenic mouse, on a DBA/2 background, mounts Kb,E65-restricted Ag-specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Mice
Share to Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Mutation

Share to Peptide Fragments

Share to Structure-Activity Relationship

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 8409380

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A conservative mutation in a class I MHC molecule outside the peptide binding groove stimulates responses to self peptides.PMID 8409380Read ↗

Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.Semantic proximity Read ↗

Recognition of a specific self-peptide: self-MHC class II complex is critical for positive selection of thymocytes expressing the D10 TCR.Semantic proximity Read ↗

Type 1 diabetes-predisposing MHC alleles influence the selection of glutamic acid decarboxylase (GAD) 65-specific T cells in a transgenic model.Semantic proximity Read ↗

Transgenic mice expressing a soluble foreign H-2 class I antigen are tolerant to allogeneic fragments presented by self class I but not to the whole membrane-bound alloantigen.Semantic proximity Read ↗

HLA class II polymorphism influences the immune response to protective antigen and susceptibility to <i>Bacillus anthracis</i>Semantic proximity Read ↗

Generation of an HLA-DQ2.5 Knock-In MouseSemantic proximity Read ↗

Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice.Semantic proximity Read ↗

Metal-specific CD4+ T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice.Semantic proximity Read ↗

The immunodominant influenza matrix t cell epitope recognized in human induces influenza protection in HLA-A2/Kb transgenic miceSemantic proximity Read ↗

Alteration at a single amino acid residue in the T cell receptor alpha chain complementarity determining region 2 changes the differentiation of naive CD4 T cells in response to antigen from T helper cell type 1 (Th1) to Th2.Semantic proximity Read ↗

Alloreactive cytotoxic T lymphocytes recognize epitopes determined by both the alpha helices and beta sheets of the class I peptide binding site.Semantic proximity Read ↗

Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.