Article
Targeted disruption of the MHC class II Aa gene in C57BL/6 mice.
International immunology - 1 Aug 1993
Köntgen F, Süss G, Stewart C, Steinmetz M, Bluethmann H
Abstract excerpt
The MHC class II gene Aa was disrupted by targeted mutation in embryonic stem (ES) cells derived from C57BL/6 mice to prevent expression of MHC class II molecules. Contrary to previous reports, the effect of the null-mutation on T cell development was investigated in C57BL/6 mice, which provide a...
Topics
- Animals
- Antigens, T-Independent
- Base Sequence
- CD4 Antigens
- CD8 Antigens
- Female
- Genes, MHC Class II
- Histocompatibility Antigens Class II
- Immunization
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation
- Phenotype
- Receptors, Antigen, T-Cell
- T-Lymphocytes