Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.

doi:10.1073/pnas.87.16.6186

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Article

Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990

Sha W C, Nelson C A, Newberry R D, Pullen J K, Pease L R, Russell J H, Loh D Y

Abstract excerpt

A specific interaction between the class I major histocompatibility complex molecule Kb and thymocytes expressing the antigen receptor from the cytolytic T lymphocyte 2C enhances maturation of T cells of the CD8 lineage in transgenic mice. By analyzing transgenic mice backcrossed to Kbm mutant strains of mice, we have identified five bm mutations of the Kb antigen-encoding gene that alter the positive selection...

Topics

Animals
Antigens, Bacterial
Antigens, Differentiation, T-Lymphocyte
Antigens, Surface
CD8 Antigens
Cytotoxicity, Immunologic
DNA Replication
Flow Cytometry
Histocompatibility Antigens Class I
Lymphocyte Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Transgenic

Mutation

Phenotype

Polymerase Chain Reaction

Receptors, Antigen, T-Cell

T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 2117275
DOI: 10.1073/pnas.87.16.6186
PMCID: PMC54497

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2117275-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.PMID 2117275Read ↗

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