Article
Generation of a Novel HLA Class I Transgenic Mouse Model Carrying a Knock-in Mutation at the β2-Microglobulin Locus.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2017
Harada Naomoto, Fukaya Satoshi, Wada Hiroshi, Goto Risa, Osada Toshihiro, Gomori Akira, Ikizawa Koichi, Sakuragi Motomu, Oda Nobuyuki
Abstract excerpt
We generated a series of monochain HLA class I knock-in (KI) mouse strains, in which a chimeric HLA class I molecule (α1/α2 domain of HLA-A*0201, HLA-A*0301, HLA-A*2402, or HLA-A*3101 and α3 domain of H-2Db) was covalently linked with 15 aa to human β2-microglobulin (β2m) and introduced into the endogenous mouse β2m locus. In homozygous KI mice, mouse β2m gene disruption resulted in loss of the endogenous H-2...
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