Article
Immune deficiency due to high copy numbers of an Ak beta transgene.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1990
Gilfillan S, Aiso S, Michie S A, McDevitt H O
Abstract excerpt
Because allelic polymorphism of the major histocompatibility complex class II antigens affects the immune response at several levels, we wished to characterize the contribution of a particular alpha or beta chain in vivo using transgenic mice. We have established and characterized 12 lines of H-2...
Topics
- Alleles
- Animals
- Antibodies, Monoclonal
- B-Lymphocytes
- Female
- Flow Cytometry
- Gene Expression
- Genes, MHC Class II
- Histocompatibility Antigens Class II
- Immunohistochemistry
- Immunologic Deficiency Syndromes
- Lymphocyte Depletion
- Male
- Mice
- Mice, Inbred Strains
- Mice, Transgenic
- Polymorphism, Genetic
- RNA, Messenger