Article
Immune deficiency due to high copy numbers of an Ak beta transgene.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1990
Gilfillan S, Aiso S, Michie S A, McDevitt H O
Abstract excerpt
Because allelic polymorphism of the major histocompatibility complex class II antigens affects the immune response at several levels, we wished to characterize the contribution of a particular alpha or beta chain in vivo using transgenic mice. We have established and characterized 12 lines of H-2s/s mice carrying from 1 to 65 copies of an Ak beta transgene. The transgene was coexpressed with the endogenous allele...
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