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Article

Severe defect in thymic development in an insertional mutant mouse model.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2007

Assarsson Erika, Chambers Benedict J, Högstrand Kari, Berntman Emma, Lundmark Carin, Fedorova Ludmila, Imreh Stefan, Grandien Alf, Cardell Susanna, Rozell Björn, Ljunggren Hans-Gustaf

Abstract excerpt

Transgenic mice were generated expressing NK1.1, an NK cell-associated receptor, under control of the human CD2 promoter. Unexpectedly, one of the founder lines, Tg66, showed a marked defect in thymic development characterized by disorganized architecture and small size. Mapping of the transgene insertion by fluorescence in situ hybridization revealed integration in chromosome 2, band G. Already from postnatal...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17404284
DOI: 10.4049/jimmunol.178.8.5018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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