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Article

The cis and trans effects of the risk variants of coronary artery disease in the Chr9p21 region.

BMC medical genomics - 10 May 2015

Zhao Wei, Smith Jennifer A, Mao Guangmei, Fornage Myriam, Peyser Patricia A, Sun Yan V, Turner Stephen T, Kardia Sharon L R

Abstract excerpt

BACKGROUND: Recent genome-wide association studies (GWAS) have shown that single nucleotide polymorphisms (SNPs) in the Chr9p21 region are associated with coronary artery disease (CAD). Most of the SNPs identified in this region are non-coding SNPs, suggesting that they may influence gene expression by cis or trans mechanisms to affect disease susceptibility. Since all cells from an individual have the same DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25958224
DOI: 10.1186/s12920-015-0094-0
PMCID: PMC4432789

Genes

CAD
ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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