Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional genomics of the CDKN2A/B locus in cardiovascular and metabolic disease: what have we learned from GWASs?

Trends in endocrinology and metabolism: TEM - 1 Apr 2015

Hannou Sarah Anissa, Wouters Kristiaan, Paumelle Réjane, Staels Bart

Abstract excerpt

Genome-wide association studies (GWASs) provide an unprecedented opportunity to examine, on a large scale, the association of common genetic variants with complex diseases like type 2 diabetes (T2D) and cardiovascular disease (CVD), thus allowing the identification of new potential disease loci. Using this approach, numerous studies have associated SNPs on chromosome 9p21.3 situated near the cyclin-dependent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 9
Share to Coronary Artery Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p15

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Diabetes Mellitus, Type 2

Share to Genetic Loci

Share to Genomics

Share to Mice, Knockout

Source

Identifiers

PMID: 25744911
DOI: 10.1016/j.tem.2015.01.008

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional genomics of the CDKN2A/B locus in cardiovascular and metabolic disease: what have we learned from GWASs?PMID 25744911Read ↗

Functional genomics of the 9p21.3 locus for atherosclerosis: clarity or confusion?Semantic proximity Read ↗

The 9p21 Locus and its Potential Role in Atherosclerosis Susceptibility; Molecular Mechanisms and Clinical Implications.Semantic proximity Read ↗

[Genetic variants, cardiovascular risk and genome-wide association studies].Semantic proximity Read ↗

Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B.Semantic proximity Read ↗

Genomics era and complex disorders: Implications of GWAS with special reference to coronary artery disease, type 2 diabetes mellitus, and cancers.Semantic proximity Read ↗

The chromosome 9p21.3 coronary heart disease risk allele is associated with altered gene expression in normal heart and vascular tissues.Semantic proximity Read ↗

Resequencing and clinical associations of the 9p21.3 region: a comprehensive investigation in the Framingham heart study.Semantic proximity Read ↗

Identification of Susceptibility Loci for Cardiovascular Disease in Adults With Hypertension, Diabetes and Dyslipidemia Semantic proximity Read ↗

The mechanisms of Chr.9p21.3 risk locus in coronary artery disease: where are we today?Semantic proximity Read ↗

Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression.Semantic proximity Read ↗

Multiethnic Genome-Wide Association Study of Subclinical Atherosclerosis in Individuals With Type 2 Diabetes.Semantic proximity Read ↗

Enhanced Megakaryopoiesis and Platelet Activity in Hypercholesterolemic, B6-Ldlr-/-, Cdkn2a-Deficient Mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.