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Article

Estrogen receptor-Beta variants are associated with increased risk of Alzheimer's disease in women with down syndrome.

Dementia and geriatric cognitive disorders - 1 Jan 2011

Zhao Qi, Lee Joseph H, Pang Deborah, Temkin Alexis, Park Naeun, Janicki Sarah C, Zigman Warren B, Silverman Wayne, Tycko Benjamin, Schupf Nicole

Abstract excerpt

BACKGROUND/AIMS: Genetic variants that affect estrogen activity may influence the risk of Alzheimer's disease (AD). We examined the relation of polymorphisms in the gene for the estrogen receptor-beta (ESR2) to the risk of AD in women with Down syndrome. METHODS: Two hundred and forty-nine women with Down syndrome, 31-70 years of age and nondemented at baseline, were followed at 14- to 18-month intervals for 4...

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Source

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Identifiers

PMID: 22156442
DOI: 10.1159/000334522
PMCID: PMC3250648

Genes

ESR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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