Article
Polymorphisms of the estrogen receptor alpha (ESR1) gene and the risk of Alzheimer's disease in a southern Chinese community.
International psychogeriatrics - 1 Oct 2009
Ma Suk L, Tang Nelson L S, Tam Cindy W C, Lui Victor W C, Lau Edmond S S, Zhang Ya P, Chiu Helen F K, Lam Linda C W
Abstract excerpt
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disease with a higher prevalence in women. Expression of estrogen receptor 1 (ESR1) gene has been identified throughout the brain. Owing to the putative neuroprotective effects of estrogen, estrogen receptor gene is a potential candidate modulating the development of AD. Preliminary associations between two polymorphisms of ESR1 (PvuII and XbaI) gene and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.