Article
Association of variants within APOE, SORL1, RUNX1, BACE1 and ALDH18A1 with dementia in Alzheimer's disease in subjects with Down syndrome.
Neuroscience letters - 7 Jan 2011
Patel Ashok, Rees Simon D, Kelly M Ann, Bain Steven C, Barnett Anthony H, Thalitaya Deepak, Prasher Vee P
Abstract excerpt
BACKGROUND: Down syndrome (DS) is caused by either complete or partial triplication of chromosome 21, affecting approximately 1/1000 live births, and it is widely accepted that individuals with DS are more likely to develop dementia of Alzheimer's disease (DAD) compared with the general population. Many studies have investigated genetic susceptibility to AD in the general population, resulting in a number of...
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