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Article

Estrogen receptor beta gene variants are associated with increased risk of Alzheimer's disease in women.

European journal of human genetics : EJHG - 1 Sept 2005

Pirskanen Mia, Hiltunen Mikko, Mannermaa Arto, Helisalmi Seppo, Lehtovirta Maarit, Hänninen Tuomo, Soininen Hilkka

Abstract excerpt

We investigated the association of five intronic single-nucleotide polymorphism (SNP) at the estrogen receptor beta (ESR2) gene locus and the susceptibility of developing Alzheimer's disease (AD) in 387 subjects with clinically diagnosed probable AD and 467 cognitively normal individuals derived from eastern Finland. According to our results, variation in the ESR2 gene is associated with an increased risk of AD...

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Source

Identifiers

PMID: 15944651
DOI: 10.1038/sj.ejhg.5201447

Genes

ESR2
APOE

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