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Article

Candidate genes for Alzheimer's disease are associated with individual differences in plasma levels of beta amyloid peptides in adults with Down syndrome.

Neurobiology of aging - 1 Oct 2015

Schupf Nicole, Lee Annie, Park Naeun, Dang Lam-Ha, Pang Deborah, Yale Alexander, Oh David Kyung-Taek, Krinsky-McHale Sharon J, Jenkins Edmund C, Luchsinger José A, Zigman Warren B, Silverman Wayne, Tycko Benjamin, Kisselev Sergey, Clark Lorraine, Lee Joseph H

Abstract excerpt

We examined the contribution of candidates genes for Alzheimer's disease (AD) to individual differences in levels of beta amyloid peptides in adults with Down syndrom, a population at high risk for AD. Participants were 254 non-demented adults with Down syndrome, 30-78 years of age. Genomic deoxy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26166206
DOI: 10.1016/j.neurobiolaging.2015.06.020
PMCID: PMC4562880

Genes

IDE
SOD1
SORCS1
APOE
CALHM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26166206-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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