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Article

APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome.

Neurology - 22 Jul 1999

Lai F, Kammann E, Rebeck G W, Anderson A, Chen Y, Nixon R A

Abstract excerpt

BACKGROUND: Alzheimer disease (AD) neuropathology is present in Down syndrome (DS) after age 35, but dementia onset varies from ages 40 to 70 years. Because of small sample sizes and nonuniform determination of dementia, previous studies produced differing results on the influence of APOE subtypes on AD in DS. OBJECTIVE: To determine the influence of the APOE genotype and gender on development of AD in adults...

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Source

Identifiers

PMID: 10430422
DOI: 10.1212/wnl.53.2.331

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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