Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variants in CYP17 and CYP19 cytochrome P450 genes are associated with onset of Alzheimer's disease in women with down syndrome.

Journal of Alzheimer's disease : JAD - 1 Jan 2012

Chace Constance, Pang Deborah, Weng Catherine, Temkin Alexis, Lax Simon, Silverman Wayne, Zigman Warren, Ferin Michel, Lee Joseph H, Tycko Benjamin, Schupf Nicole

Abstract excerpt

CYP17 and CYP19 are involved in the peripheral synthesis of estrogens, and polymorphisms in CYP17 and CYP19 have been associated with increased risk of estrogen-related disorders. Women with Down syndrome (DS) have early onset and high risk for Alzheimer's disease (AD). We conducted a prospective community-based cohort study to examine the relationship between SNPs in CYP17 and CYP19 and cumulative incidence of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aromatase
Share to Disability Evaluation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Down Syndrome

Share to Menopause

Share to Psychiatric Status Rating Scales

Share to Radioimmunoassay

Share to Sex Hormone-Binding Globulin

Share to Steroid 17-alpha-Hydroxylase

Source

Open in PubMed Open full text

Identifiers

PMID: 22057025
DOI: 10.3233/JAD-2011-110860
PMCID: PMC3276705

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variants in CYP17 and CYP19 cytochrome P450 genes are associated with onset of Alzheimer's disease in women with down syndrome.PMID 22057025Read ↗

Estrogen receptor-Beta variants are associated with increased risk of Alzheimer's disease in women with down syndrome.Semantic proximity Read ↗

Earlier onset of Alzheimer's disease in men with Down syndrome.Semantic proximity Read ↗

Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome.Semantic proximity Read ↗

Genetic variation of CYP19 (aromatase) gene influences age at onset of Alzheimer's disease in women.Semantic proximity Read ↗

Association of variants within APOE, SORL1, RUNX1, BACE1 and ALDH18A1 with dementia in Alzheimer's disease in subjects with Down syndrome.Semantic proximity Read ↗

APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome.Semantic proximity Read ↗

Candidate genes for Alzheimer's disease are associated with individual differences in plasma levels of beta amyloid peptides in adults with Down syndrome.Semantic proximity Read ↗

Polymorphisms in the CYP19 gene confer increased risk for Alzheimer disease.Semantic proximity Read ↗

CYP19 haplotypes increase risk for Alzheimer’s diseaseSemantic proximity Read ↗

Alzheimer's disease in Down syndrome: An overlooked population for prevention trialsSemantic proximity Read ↗

Candidate gene analysis for Alzheimer's disease in adults with Down syndrome.Semantic proximity Read ↗

Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.