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Article

Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome.

Dementia and geriatric cognitive disorders - 1 Jan 2008

Schupf Nicole, Lee Joseph H, Wei Michelle, Pang Deborah, Chace Constance, Cheng Rong, Zigman Warren B, Tycko Benjamin, Silverman Wayne

Abstract excerpt

BACKGROUND: Genetic variants that affect estrogen activity may influence the risk of Alzheimer's disease (AD). Two tightly linked polymorphisms (PvuII and XbaI) in the first intron of estrogen receptor 1 (ESR1), the gene for ER-alpha, have been reported to influence estrogen receptor expression and may influence the risk of AD. METHODS: We examined the relation of polymorphisms in ESR1 to the risk of AD in women...

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Aged
Alzheimer Disease
Apolipoprotein E4
Down Syndrome
Estrogen Receptor alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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Open in PubMed Open full text

Identifiers

PMID: 18408366
DOI: 10.1159/000126495
PMCID: PMC2430887

Genes

ESR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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