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Article

Polymorphisms in the innate immune IFIH1 gene, frequency of enterovirus in monthly fecal samples during infancy, and islet autoimmunity.

PloS one - 1 Jan 2011

Witsø Elisabet, Tapia German, Cinek Ondrej, Pociot Flemming Michael, Stene Lars C, Rønningen Kjersti S

Abstract excerpt

Interferon induced with helicase C domain 1 (IFIH1) senses and initiates antiviral activity against enteroviruses. Genetic variants of IFIH1, one common and four rare SNPs have been associated with lower risk for type 1 diabetes. Our aim was to test whether these type 1 diabetes-associated IFIH1 polymorphisms are associated with the occurrence of enterovirus infection in the gut of healthy children, or influence...

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Share to Autoimmunity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

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Share to Immunity, Innate

Share to Interferon-Induced Helicase, IFIH1

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Source

Open in PubMed Open full text

Identifiers

PMID: 22110759
DOI: 10.1371/journal.pone.0027781
PMCID: PMC3215739

Genes

IFIH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Polymorphisms in the innate immune IFIH1 gene, frequency of enterovirus in monthly fecal samples during infancy, and islet autoimmunity.PMID 22110759Read ↗

Enterovirus RNA in peripheral blood may be associated with the variants of rs1990760, a common type 1 diabetes associated polymorphism in IFIH1.Semantic proximity Read ↗

Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage.Semantic proximity Read ↗

An interferon-induced helicase (IFIH1) gene polymorphism associates with different rates of progression from autoimmunity to type 1 diabetes.Semantic proximity Read ↗

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Population genetics of IFIH1: ancient population structure, local selection, and implications for susceptibility to type 1 diabetes.Semantic proximity Read ↗

An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets.Semantic proximity Read ↗

The IFIH1-A946T risk variant promotes diabetes in a sex-dependent mannerSemantic proximity Read ↗

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Cumulative effect of IFIH1 variants and increased gene expression associated with type 1 diabetes.Semantic proximity Read ↗

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