Article
Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage.
Diabetologia - 1 Oct 2022
Sioofy-Khojine Amir-Babak, Richardson Sarah J, Locke Jonathan M, Oikarinen Sami, Nurminen Noora, Laine Antti-Pekka, Downes Kate, Lempainen Johanna, Todd John A, Veijola Riitta, Ilonen Jorma, Knip Mikael, Morgan Noel G, Hyöty Heikki, Peakman Mark, Eichmann Martin
Abstract excerpt
AIMS/HYPOTHESIS: Enteroviral infection has been implicated consistently as a key environmental factor correlating with the appearance of autoimmunity and/or the presence of overt type 1 diabetes, in which pancreatic insulin-producing beta cells are destroyed by an autoimmune response. Genetic predisposition through variation in the type 1 diabetes risk gene IFIH1 (interferon induced with helicase C domain 1),...
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