Article
Enterovirus RNA in peripheral blood may be associated with the variants of rs1990760, a common type 1 diabetes associated polymorphism in IFIH1.
PloS one - 1 Jan 2012
Cinek Ondrej, Tapia German, Witsø Elisabet, Kramna Lenka, Holkova Katerina, Rasmussen Trond, Stene Lars C, Rønningen Kjersti S
Abstract excerpt
OBJECTIVE: Polymorphisms in the IFIH1 (common rs1990760 and four rare rs35667974, rs35337543, rs35744605, rs35732034) have been convincingly associated with type 1 diabetes. The encoded protein (interferon-induced helicase C domain-containing protein 1) senses double-stranded RNA during replication of Picornavirales, including Enterovirus, a genus suspected in the etiology of type 1 diabetes. We therefore...