Article
Cumulative effect of IFIH1 variants and increased gene expression associated with type 1 diabetes.
Diabetes research and clinical practice - 1 Feb 2015
Zurawek Magdalena, Fichna Marta, Fichna Piotr, Skowronska Bogda, Dzikiewicz-Krawczyk Agnieszka, Januszkiewicz Danuta, Nowak Jerzy
Abstract excerpt
AIMS: IFIH1 (Interferon Induced with Helicase C domain 1) gene encodes a sensor of double-stranded RNA, which initiates antiviral activity. Recent studies have indicated the association of rare and common IFIH1 variants with type 1 diabetes mellitus (T1D). The aim of this study was to investigate whether polymorphisms in the IFIH1 locus are a risk factor for T1D in Caucasian patients from Poland. METHODS: We...
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