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Article

Population genetics of IFIH1: ancient population structure, local selection, and implications for susceptibility to type 1 diabetes.

Molecular biology and evolution - 1 Nov 2010

Fumagalli Matteo, Cagliani Rachele, Riva Stefania, Pozzoli Uberto, Biasin Mara, Piacentini Luca, Comi Giacomo P, Bresolin Nereo, Clerici Mario, Sironi Manuela

Abstract excerpt

The human interferon induced with helicase C domain 1 (IFIH1) gene encodes a sensor of double-strand RNA involved in innate immunity against viruses, indicating that this gene is a likely target of virus-driven selective pressure. Notably, IFIH1 also plays a role in autoimmunity, as common and rare polymorphisms in this gene have been associated with type 1 diabetes (T1D). We analyzed the evolutionary history of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20538742
DOI: 10.1093/molbev/msq141

Genes

IFIH1

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Population genetics of IFIH1: ancient population structure, local selection, and implications for susceptibility to type 1 diabetes.PMID 20538742Read ↗

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Interferon induced with helicase C domain 1 (IFIH1): trends on helicase domain and type 1 diabetes onset.Semantic proximity Read ↗

An interferon-induced helicase (IFIH1) gene polymorphism associates with different rates of progression from autoimmunity to type 1 diabetes.Semantic proximity Read ↗

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.Semantic proximity Read ↗

The interferon-induced helicase IFIH1 Ala946Thr polymorphism is associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations.Semantic proximity Read ↗

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