Article
Mapping of homozygous deletions in verified esophageal adenocarcinoma cell lines and xenografts.
Genes, chromosomes & cancer - 1 Mar 2012
Boonstra Jurjen J, van Marion Ronald, Douben Hannie J C W, Lanchbury Jerry S, Timms Kirsten M, Abkevich Victor, Tilanus Hugo W, de Klein Annelies, Dinjens Winand N M
Abstract excerpt
Human esophageal adenocarcinoma (EAC) cell lines and xenografts are powerful tools in the search for genetic alterations because these models are composed of pure human cancer cell populations without admixture of normal human cells. In particular detection of homozygous deletions (HDs) is easier using these pure populations of cancer cells. Identification of HDs could potentially lead to the subsequent...
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