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Article

Genome-wide catalogue of chromosomal aberrations in barrett's esophagus and esophageal adenocarcinoma: a high-density single nucleotide polymorphism array analysis.

Cancer prevention research (Philadelphia, Pa.) - 1 Sept 2010

Gu Jian, Ajani Jaffer A, Hawk Ernest T, Ye Yuanqing, Lee Jeffrey H, Bhutani Manoop S, Hofstetter Wayne L, Swisher Stephen G, Wang Kenneth K, Wu Xifeng

Abstract excerpt

To better understand the molecular mechanisms behind esophageal adenocarcinoma (EAC) tumorigenesis, we used high-density single nucleotide polymorphism arrays to profile chromosomal aberrations at each of the four sequential progression stages, Barrett's metaplasia (BM), low-grade dysplasia (LGD), high-grade dysplasia (HGD), and EAC, in 101 patients. We observed a significant trend toward increasing loss of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20651033
DOI: 10.1158/1940-6207.CAPR-09-0265
PMCID: PMC3932797

Genes

HGD
FHIT
RUNX1
WWOX
CTSB
DMD
GMDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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