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Article

Genome-wide analysis of esophageal adenocarcinoma yields specific copy number aberrations that correlate with prognosis.

Genes, chromosomes & cancer - 1 Apr 2014

Frankel Adam, Armour Nicola, Nancarrow Derek, Krause Lutz, Hayward Nicholas, Lampe Guy, Smithers B Mark, Barbour Andrew

Abstract excerpt

The incidence of esophageal adenocarcinoma (EAC) has been increasing rapidly for the past 3 decades in Western (Caucasian) populations. Curative treatment is based around esophagectomy, which has a major impact on quality of life. For those suitable for treatment with curative intent, 5-year survival is ∼30%. More accurate prognostic tools are therefore needed, and copy number aberrations (CNAs) may offer the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24446147
DOI: 10.1002/gcc.22143

Genes

EGFR
ERBB2
FHIT
KLF12
MYC
PTPRD
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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