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Article

Integrated genomics and comprehensive validation reveal drivers of genomic evolution in esophageal adenocarcinoma.

Communications biology - 24 May 2021

Kumar Subodh, Buon Leutz, Talluri Srikanth, Roncador Marco, Liao Chengcheng, Zhao Jiangning, Shi Jialan, Chakraborty Chandraditya, Gonzalez Gabriel, Tai Yu-Tzu, Prabhala Rao, Samur Mehmet K, Munshi Nikhil C, Shammas Masood A

Abstract excerpt

Esophageal adenocarcinoma (EAC) is associated with a marked genomic instability, which underlies disease progression and development of resistance to treatment. In this study, we used an integrated genomics approach to identify a genomic instability signature. Here we show that elevated expression of this signature correlates with poor survival in EAC as well as three other cancers. Knockout and overexpression...

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Identifiers

PMID: 34031527
DOI: 10.1038/s42003-021-02125-x
PMCID: PMC8144613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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