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Article

Genome-wide copy number analysis in esophageal adenocarcinoma using high-density single-nucleotide polymorphism arrays.

Cancer research - 1 Jun 2008

Nancarrow Derek J, Handoko Herlina Y, Smithers B Mark, Gotley David C, Drew Paul A, Watson David I, Clouston Andrew D, Hayward Nicholas K, Whiteman David C

Abstract excerpt

We applied whole-genome single-nucleotide polymorphism arrays to define a comprehensive genetic profile of 23 esophageal adenocarcinoma (EAC) primary tumor biopsies based on loss of heterozygosity (LOH) and DNA copy number changes. Alterations were common, averaging 97 (range, 23-208) per tumor. LOH and gains averaged 33 (range, 3-83) and 31 (range, 11-73) per tumor, respectively. Copy neutral LOH events averaged...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18519675
DOI: 10.1158/0008-5472.CAN-07-6710

Genes

FHIT
MYC
BCL9
CTAGE1
DMD
GALR1
SMAD4
WWOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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