Article
Targeted Sequencing of Sorted Esophageal Adenocarcinoma Cells Unveils Known and Novel Mutations in the Separated Subpopulations.
Clinical and translational gastroenterology - 1 Sept 2020
Isidori Federica, Bozzarelli Isotta, Mastracci Luca, Malvi Deborah, Lugaresi Marialuisa, Molinari Chiara, Söderström Henna, Räsänen Jari, D'Errico Antonia, Fiocca Roberto, Seri Marco, Krishnadath Kausilia K, Bonora Elena, Mattioli Sandro
Abstract excerpt
INTRODUCTION: Our study aimed at investigating tumor heterogeneity in esophageal adenocarcinoma (EAC) cells regarding clinical outcomes. METHODS: Thirty-eight surgical EAC cases who underwent gastroesophageal resection with lymph node dissection in 3 university centers were included. Archival material was analyzed via high-throughput cell sorting technology and targeted sequencing of 63 cancer-related genes....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.