Discrimination between bacteriophage T3 and T7 promoters by the T3 and T7 RNA polymerases depends primarily upon a three base-pair region located 10 to 12 base-pairs upstream from the start site.

doi:10.1016/s0022-2836(05)80091-9

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Article

Discrimination between bacteriophage T3 and T7 promoters by the T3 and T7 RNA polymerases depends primarily upon a three base-pair region located 10 to 12 base-pairs upstream from the start site.

Journal of molecular biology - 5 Sept 1990

Klement J F, Moorefield M B, Jorgensen E, Brown J E, Risman S, McAllister W T

Abstract excerpt

The bacteriophage T3 and T7 RNA polymerases are closely related, yet are highly specific for their own promoter sequences. To understand the basis of this specificity, T7 promoter variant that contain substitutions of T3-specific base-pairs at one or more positions within the T7 promoter consensu...

Topics

Base Composition
Base Sequence
Cloning, Molecular
DNA-Directed RNA Polymerases
Escherichia coli
Genetic Variation
Molecular Sequence Data
Oligonucleotide Probes
Promoter Regions, Genetic
Sequence Homology, Nucleic Acid
T-Phages
Templates, Genetic

Source

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Identifiers

PMID: 2204706
DOI: 10.1016/s0022-2836(05)80091-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2204706-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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