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Article

Reduced expression of lipoic acid synthase accelerates diabetic nephropathy.

Journal of the American Society of Nephrology : JASN - 1 Jan 2012

Yi Xianwen, Xu Longquan, Hiller Sylvia, Kim Hyung-Suk, Nickeleit Volker, James Leighton R, Maeda Nobuyo

Abstract excerpt

Oxidative stress contributes to the pathogenesis of diabetic nephropathy. In mitochondria, lipoic acid synthase produces α-lipoic acid, an antioxidant and an essential cofactor in α-ketoacid dehydrogenase complexes, which participate in glucose oxidation and ATP generation. Administration of lipoic acid abrogates diabetic nephropathy in animal models, but whether lower production of endogenous lipoic acid...

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Source

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Identifiers

PMID: 22021711
DOI: 10.1681/ASN.2011010003
PMCID: PMC3269922

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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