Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content.

Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2003

Finck Brian N, Han Xianlin, Courtois Michael, Aimond Franck, Nerbonne Jeanne M, Kovacs Attila, Gross Richard W, Kelly Daniel P

Abstract excerpt

To explore the role of peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated derangements in myocardial metabolism in the pathogenesis of diabetic cardiomyopathy, insulinopenic mice with PPARalpha deficiency (PPARalpha(-/-)) or cardiac-restricted overexpression [myosin heavy chain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ceramides
Share to Diabetes Mellitus, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetic Angiopathies

Share to Dietary Fats

Share to Echocardiography

Share to Electrophysiology

Share to Glutathione

Share to Receptors, Cytoplasmic and Nuclear

Source

Open in PubMed Open full text

Identifiers

PMID: 12552126
DOI: 10.1073/pnas.0336724100
PMCID: PMC298755

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12552126-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content.PMID 12552126Read ↗

The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.Semantic proximity Read ↗

CD36 deficiency rescues lipotoxic cardiomyopathy.Semantic proximity Read ↗

High-fat feeding in cardiomyocyte-restricted PPARdelta knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes.Semantic proximity Read ↗

Rescue of cardiomyopathy in peroxisome proliferator-activated receptor-alpha transgenic mice by deletion of lipoprotein lipase identifies sources of cardiac lipids and peroxisome proliferator-activated receptor-alpha activators.Semantic proximity Read ↗

Novel Insights Into the Pathogenesis of Diabetic Cardiomyopathy and Pharmacological StrategiesSemantic proximity Read ↗

Molecular Dysfunction and Phenotypic Derangement in Diabetic CardiomyopathySemantic proximity Read ↗

A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes.Semantic proximity Read ↗

Role of 14-3-3η protein on cardiac fatty acid metabolism and macrophage polarization after high fat diet induced type 2 diabetes mellitus.Semantic proximity Read ↗

The heme oxygenase system selectively enhances the anti-inflammatory macrophage-M2 phenotype, reduces pericardial adiposity, and ameliorated cardiac injury in diabetic cardiomyopathy in Zucker diabetic fatty rats.Semantic proximity Read ↗

Mice with cardiac overexpression of peroxisome proliferator-activated receptor γ have impaired repolarization and spontaneous fatal ventricular arrhythmias.Semantic proximity Read ↗

Metabolic reprogramming via PPARα signaling in cardiac hypertrophy and failure: From metabolomics to epigeneticsSemantic proximity Read ↗

Myeloid peroxisome proliferator-activated receptor gamma deficiency aggravates myocardial infarction in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.