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Article

Lipotoxicity in diabetic nephropathy: the potential role of fatty acid oxidation.

Clinical journal of the American Society of Nephrology : CJASN - 1 Dec 2010

Murea Mariana, Freedman Barry I, Parks John S, Antinozzi Peter A, Elbein Steven C, Ma Lijun

Abstract excerpt

Cellular toxicity mediated by lipids (lipotoxicity) has been implicated in the pathophysiology of metabolic syndrome and diabetes mellitus. Genetic analyses now implicate lipotoxicity in susceptibility to type 2 diabetes mellitus-associated nephropathy (T2DN), a pathway that had previously been unexplored. A genome-wide association study in Japanese patients identified a single nucleotide polymorphism in the...

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Share to Acetyl-CoA Carboxylase
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetic Nephropathies

Share to Fatty Acids

Share to Oxidation-Reduction

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 21051750
DOI: 10.2215/CJN.08160910

Genes

ACACB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Lipotoxicity in diabetic nephropathy: the potential role of fatty acid oxidation.PMID 21051750Read ↗

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