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Article

Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes.

Diabetes - 1 Aug 2005

Wang Zhuowei, Jiang Tao, Li Jinping, Proctor Gregory, McManaman James L, Lucia Scott, Chua Streamson, Levi Moshe

Abstract excerpt

Diabetic kidney disease has been associated with the presence of lipid deposits, but the mechanisms for the lipid accumulation have not been fully determined. In the present study, we found that db/db mice on the FVB genetic background with loss-of-function mutation of the leptin receptor (FVB-Lepr(db) mice or FVBdb/db) develop severe diabetic nephropathy, including glomerulosclerosis, tubulointerstitial...

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Identifiers

PMID: 16046298
DOI: 10.2337/diabetes.54.8.2328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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