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Article

Reduction of Superoxide Dismutase 1 Delays Regeneration of Cardiotoxin-Injured Skeletal Muscle in KK/Ta-Ins2Akita Mice with Progressive Diabetic Nephropathy.

International journal of molecular sciences - 23 May 2021

Takahashi Yuya, Shimizu Tatsunori, Kato Shunsuke, Nara Mitsuhiko, Suganuma Yumi, Sato Takehiro, Morii Tsukasa, Yamada Yuichiro, Fujita Hiroki

Abstract excerpt

Superoxide dismutase (SOD) is a major antioxidant enzyme for superoxide removal, and cytoplasmic SOD (SOD1) is expressed as a predominant isoform in all cells. We previously reported that renal SOD1 deficiency accelerates the progression of diabetic nephropathy (DN) via increasing renal oxidative stress. To evaluate whether the degree of SOD1 expression determines regeneration capacity and sarcopenic phenotypes...

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Identifiers

PMID: 34071003
DOI: 10.3390/ijms22115491
PMCID: PMC8197123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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