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Article

Lipocalin-2 derived from adipose tissue mediates aldosterone-induced renal injury.

JCI insight - 6 Sept 2018

Sun Wai Yan, Bai Bo, Luo Cuiting, Yang Kangmin, Li Dahui, Wu Donghai, Félétou Michel, Villeneuve Nicole, Zhou Yang, Yang Junwei, Xu Aimin, Vanhoutte Paul M, Wang Yu

Abstract excerpt

Lipocalin-2 is not only a sensitive biomarker, but it also contributes to the pathogenesis of renal injuries. The present study demonstrates that adipose tissue-derived lipocalin-2 plays a critical role in causing both chronic and acute renal injuries. Four-week treatment with aldosterone and high salt after uninephrectomy (ANS) significantly increased both circulating and urinary lipocalin-2, and it induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30185654
DOI: 10.1172/jci.insight.120196
PMCID: PMC6171815

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