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Article

Deamidated lipocalin-2 induces endothelial dysfunction and hypertension in dietary obese mice.

Journal of the American Heart Association - 10 Apr 2014

Song Erfei, Fan Pengcheng, Huang Bosheng, Deng Han-Bing, Cheung Bernard Man Yung, Félétou Michel, Vilaine Jean-Paul, Villeneuve Nicole, Xu Aimin, Vanhoutte Paul M, Wang Yu

Abstract excerpt

BACKGROUND: Lipocalin-2 is a proinflammatory adipokine upregulated in obese humans and animals. A pathogenic role of lipocalin-2 in hypertension has been suggested. Mice lacking lipocalin-2 are protected from dietary obesity-induced cardiovascular dysfunctions. Administration of lipocalin-2 causes abnormal vasodilator responses in mice on a high-fat diet (HFD). METHODS AND RESULTS: Wild-type and lipocalin-2...

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Source

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Identifiers

PMID: 24721803
DOI: 10.1161/JAHA.114.000837
PMCID: PMC4187505

Genes

MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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