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Article

Reduction of renal superoxide dismutase in progressive diabetic nephropathy.

Journal of the American Society of Nephrology : JASN - 1 Jun 2009

Fujita Hiroki, Fujishima Hiromi, Chida Shinsuke, Takahashi Keiko, Qi Zhonghua, Kanetsuna Yukiko, Breyer Matthew D, Harris Raymond C, Yamada Yuichiro, Takahashi Takamune

Abstract excerpt

Superoxide excess plays a central role in tissue damage that results from diabetes, but the mechanisms of superoxide overproduction in diabetic nephropathy (DN) are incompletely understood. In the present study, we investigated the enzyme superoxide dismutase (SOD), a major defender against superoxide, in the kidneys during the development of murine DN. We assessed SOD activity and the expression of SOD isoforms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19470681
DOI: 10.1681/ASN.2008080844
PMCID: PMC2689908

Genes

SOD1
SOD3
SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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