Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endogenous Production of Lipoic Acid Is Essential for Mouse Development

31 Aug 2005

Abstract excerpt

alpha-Lipoic acid (LA) is a cofactor for mitochondrial alpha-ketoacid dehydrogenase complexes and is one of the most potent, natural antioxidants. Reduction of oxidative stress by LA supplementation has been demonstrated in patients with diabetic neuropathy and in animal models. To determine how normal development or pathological conditions are affected by genetic alterations in the ability of mammalian cells to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical Acid Research Studies
Share to Bipolar Disorder and Treatment
Share to Electrolyte and hormonal disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16135825
DOI: 10.1128/mcb.25.18.8387-8392.2005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endogenous Production of Lipoic Acid Is Essential for Mouse DevelopmentPMID 16135825Read ↗

Reduced expression of lipoic acid synthase accelerates diabetic nephropathy.Semantic proximity Read ↗

Lessons from the gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) null mouse model: a role in steroidogenesis, but not result in X-ALD phenotype.Semantic proximity Read ↗

Animal models for X-linked sideroblastic anemia.Semantic proximity Read ↗

Development of head organizer of the mouse embryo depends on a high level of mitochondrial metabolism.Semantic proximity Read ↗

Knockout studies reveal an important role of Plasmodium lipoic acid protein ligase A1 for asexual blood stage parasite survival.Semantic proximity Read ↗

Knockout of the l-pgds gene aggravates obesity and atherosclerosis in miceSemantic proximity Read ↗

Aortic wall damage in mice unable to synthesize ascorbic acid.Semantic proximity Read ↗

Systemic deficiency of mouse arachidonate 15-lipoxygenase induces defective erythropoiesis and transgenic expression of the human enzyme rescues this phenotype.Semantic proximity Read ↗

Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply.Semantic proximity Read ↗

Effects of acetyl L-carnitine on zebrafish embryos: Phenotypic and gene expression studies.Semantic proximity Read ↗

Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development.Semantic proximity Read ↗

Inducible nitric oxide synthase gene deficiency counteracts multiple manifestations of peripheral neuropathy in a streptozotocin-induced mouse model of diabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.