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Article

Dscam mutation leads to hydrocephalus and decreased motor function.

Protein & cell - 1 Aug 2011

Xu Yiliang, Ye Haihong, Shen Yan, Xu Qi, Zhu Li, Liu Jianghong, Wu Jane Y

Abstract excerpt

The nervous system is one of the most complicated organ systems in invertebrates and vertebrates. Down syndrome cell adhesion molecule (DSCAM) of the immunoglobulin (Ig) superfamily is expressed widely in the nervous system during embryonic development. Previous studies in Drosophila suggest that Dscam plays important roles in neural development including axon branching, dendritic tiling and cell spacing....

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Source

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Identifiers

PMID: 21904980
DOI: 10.1007/s13238-011-1072-8
PMCID: PMC3893070

Genes

DSCAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Dscam mutation leads to hydrocephalus and decreased motor function.PMID 21904980Read ↗

DSCAM contributes to dendrite arborization and spine formation in the developing cerebral cortex.Semantic proximity Read ↗

Restoring DSCAM expression rescues neuronal morphology and axon guidance deficits in Down syndromeSemantic proximity Read ↗

A novel mouse Dscam mutation inhibits localization and shedding of DSCAM.Semantic proximity Read ↗

DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse modelsSemantic proximity Read ↗

Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity.Semantic proximity Read ↗

Human down syndrome cell adhesion molecules (DSCAMs) are functionally conserved with Drosophila Dscam[TM1] isoforms in controlling neurodevelopment.Semantic proximity Read ↗

DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous systemSemantic proximity Read ↗

Potential involvement of DSCAML1 mutations in neurodevelopmental disorders.Semantic proximity Read ↗

<i>Dscam</i> gene triplication causes neocortical overinhibition in Down syndromeSemantic proximity Read ↗

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The role of Down syndrome cell adhesion molecule in Down syndromeSemantic proximity Read ↗

Dscam diversity is essential for neuronal wiring and self-recognition.Semantic proximity Read ↗

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