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The role of Down syndrome cell adhesion molecule in Down syndrome

1 Feb 2024

Abstract excerpt

Down syndrome (DS) is caused by the presence of an extra copy of the entire or a portion of human chromosome 21 (HSA21). This genomic alteration leads to elevated expression of numerous HSA21 genes, resulting in a variety of health issues in individuals with DS. Among the genes located in the DS "critical region" of HSA21, Down syndrome cell adhesion molecule (DSCAM) plays an important role in neuronal...

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PMID: 38515781
DOI: 10.1515/mr-2023-0056

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