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Article

Potential involvement of DSCAML1 mutations in neurodevelopmental disorders.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Mar 2021

Ogata Shigehiro, Hashizume Koichi, Hayase Yoneko, Kanno Yukie, Hori Kei, Balan Shabeesh, Yoshikawa Takeo, Takahashi Hidehiko, Taya Shinichiro, Hoshino Mikio

Abstract excerpt

The molecular mechanisms underlying neurodevelopmental disorders (NDDs) remain unclear. We previously identified Down syndrome cell adhesion molecule like 1 (Dscaml1) as a responsible gene for Ihara epileptic rat (IER), a rat model for human NDDs with epilepsy. However, the relationship between NDDs and DSCAML1 in humans is still elusive. In this study, we screened databases of autism spectrum disorders (ASD),...

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PMID: 33501714
DOI: 10.1111/gtc.12831

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