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Article

Dscam diversity is essential for neuronal wiring and self-recognition.

Nature - 13 Sept 2007

Hattori Daisuke, Demir Ebru, Kim Ho Won, Viragh Erika, Zipursky S Lawrence, Dickson Barry J

Abstract excerpt

Neurons are thought to use diverse families of cell-surface molecules for cell recognition during circuit assembly. In Drosophila, alternative splicing of the Down syndrome cell adhesion molecule (Dscam) gene potentially generates 38,016 closely related transmembrane proteins of the immunoglobulin superfamily, each comprising one of 19,008 alternative ectodomains linked to one of two alternative transmembrane...

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Identifiers

PMID: 17851526
DOI: 10.1038/nature06099
PMCID: PMC2691715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dscam diversity is essential for neuronal wiring and self-recognition.PMID 17851526Read ↗

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Cell autonomy of DSCAM function in retinal development.Semantic proximity Read ↗

The molecular diversity of Dscam is functionally required for neuronal wiring specificity in Drosophila.Semantic proximity Read ↗

Intron-targeted mutagenesis reveals roles for <i>Dscam1</i> RNA pairing-mediated splicing bias in neuronal wiringSemantic proximity Read ↗

Generation of recognition diversity in the nervous system.Semantic proximity Read ↗

Stochastic splicing and deterministic inclusion of variable exons promote diversification of <i>Down Syndrome Cell Adhesion Molecule</i> expressionSemantic proximity Read ↗

Massive expansions of Dscam splicing diversity via staggered homologous recombination during arthropod evolution.Semantic proximity Read ↗

Homophilic Dscam interactions control complex dendrite morphogenesis.Semantic proximity Read ↗

Analysis of Dscam diversity in regulating axon guidance in Drosophila mushroom bodies.Semantic proximity Read ↗

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