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Article

Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity.

Cell - 9 Jun 2000

Schmucker D, Clemens J C, Shu H, Worby C A, Xiao J, Muda M, Dixon J E, Zipursky S L

Abstract excerpt

A Drosophila homolog of human Down syndrome cell adhesion molecule (DSCAM), an immunoglobulin superfamily member, was isolated by its affinity to Dock, an SH3/SH2 adaptor protein required for axon guidance. Dscam binds directly to both Dock's SH2 and SH3 domains. Genetic studies revealed that Dscam, Dock and Pak, a serine/threonine kinase, act together to direct pathfinding of Bolwig's nerve, containing a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10892653
DOI: 10.1016/s0092-8674(00)80878-8

Genes

DSCAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity.PMID 10892653Read ↗

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