Article

Restoring DSCAM expression rescues neuronal morphology and axon guidance deficits in Down syndrome

2025-07-31

Abstract excerpt

Down syndrome (DS) results from the triplication of human chromosome 21 (HSA21) and is the leading cause of intellectual disability. Down syndrome cell adhesion molecule ( DSCAM ) is located on HSA21 and is overproduced in DS. DSCAM is a receptor for netrin-1 and important for neural wiring in the developing brain. Using a Dscam gain-of-function mouse model and human induced pluripotent stem cell (hiPSC)-derived...

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Literature Corpus work: 02f17fa6-f3de-54cb-8f3f-178f7976ea8f
DOI: 10.1101/2025.07.25.666804

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